Tandem Henry/oxa-Michael route to the 1,3-disubstituted-1,3-dihydrobenzo[c]furan system |
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| Authors: | Frederick A. Luzzio Otome E. Okoromoba |
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| Affiliation: | Department of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, KY 40292, USA |
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| Abstract: | The reaction of ortho-formyl cinnamates and ortho-formyl-α-benzalketones with suitably substituted alkylnitro compounds in the presence of 1,1,3,3-tetramethylguanidine results in the formation of 1,3-disubstituted dihydroisobenzofurans. The reaction mechanism entails a base-mediated nitronate addition to the aryl formyl group followed by intramolecular alcoholate addition to the unsaturated component that then affords the isobenzofuran system. |
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| Keywords: | Isobenzofurans Henry reaction Alkylnitro compounds 1,1,3,3-Tetramethylguanidine Heck reaction |
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