| 3-取代吲哚衍生物抗肿瘤活性研究进展 |
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| 引用本文： | 唐震华,刘佳敏,付毅红,胡伟男,王贞超,欧阳贵平.3-取代吲哚衍生物抗肿瘤活性研究进展[J].化学通报,2021,84(1):47-52. |
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| 作者姓名： | 唐震华 刘佳敏 付毅红 胡伟男 王贞超 欧阳贵平 |
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| 作者单位： | 贵州大学药学院 贵阳550025;贵州大学药学院 贵阳550025;贵州医科大学药用植物功效与利用实验室 贵阳550014;贵州大学药学院 贵阳550025;贵州医科大学药用植物功效与利用实验室 贵阳550014;贵州省合成药物工程实验室 贵阳 550025 |
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| 基金项目： | 国家自然科学基金项目(21867004)、药用植物功效与利用国家重点实验室项目(FAMP201801K)、贵州省科技计划平台项目(黔科合平台人才20185781)和贵州省科技计划项目(黔科合基础20181051)资助 |
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| 摘 要： | 吲哚是一种自然界中广泛存在的化合物,具有抗肿瘤、抗氧化、抗菌等生物活性。在吲哚3-位引入不同的取代基,进行结构的修饰与改造一直是药物研究的热点。本文归纳总结了近年来相关的文献,对吡唑及吡唑啉类、二唑及三唑类、与2-位成环类等不同杂环取代的3-取代吲哚衍生物的抗肿瘤活性进行系统性的综述,以期为高活性抗肿瘤药物的研发提供一定的理论基础。
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| 关 键 词： | 3-取代吲哚 杂环 抗肿瘤活性 |
| 收稿时间： | 2020/6/28 0:00:00 |
| 修稿时间： | 2020/8/30 0:00:00 |
Progress in Antitumor Activity of 3-Substituted Indole Derivatives |
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| Tang Zhenhu,Liu Jiamin,Fu Yihong,Hu Weinan,Wang Zhenchao,Ouyang Guiping.Progress in Antitumor Activity of 3-Substituted Indole Derivatives[J].Chemistry,2021,84(1):47-52. |
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| Authors: | Tang Zhenhu Liu Jiamin Fu Yihong Hu Weinan Wang Zhenchao Ouyang Guiping |
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| Institution: | School of Pharmacy Guizhou University,,,,, |
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| Abstract: | Indole is a compound widely found in nature, having a variety of biological activities like antitumor, antioxidant and antibacterial. The introduction of different substituents at the third position on the indole ring for structural modification and transformation has always been a drug research hotspot. This article summarized the related literature in recent years, and the antitumor activities of 3-substitution indole derivatives with the different heterocycle substituents such as pyrazoles and pyrazolines, diazoles and triazoles, 2-rings were systematically reviewed in order to provide a theoretical basis for the development of highly active antitumor drugs. |
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| Keywords: | 3-substitution indole heterocycle antitumor activity research advance |
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