| 戊唑醇对映体在新型纤维素键合手性固定相上的拆分 |
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| 引用本文： | 明永飞,赵亮,张红丽,师彦平,李永民.戊唑醇对映体在新型纤维素键合手性固定相上的拆分[J].高等学校化学学报,2007,28(2):258-260. |
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| 作者姓名： | 明永飞 赵亮 张红丽 师彦平 李永民 |
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| 作者单位： | 1. 中国科学院兰州化学物理研究所,甘肃省天然药物重点实验室,兰州,730000;中国科学院研究生院,北京,110009
2. 中国科学院兰州化学物理研究所,甘肃省天然药物重点实验室,兰州,730000 |
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| 基金项目： | 国家自然科学基金
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甘肃省自然科学基金
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中国科学院"西部之光"人才培养计划 |
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| 摘 要： | 利用4,4-二苯基甲基二异氰酸酯作为连接臂, 采用6-位选择键合法制备了键合型纤维素-(3,5-二甲基苯基氨基甲酸酯)固定相, 并将其应用于戊唑醇的手性分离, 还考察了异丙醇的浓度、不同的醇类改性剂、四氢呋喃以及三氯甲烷对戊唑醇在该固定相上的手性分离的影响.
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| 关 键 词： | 键合 手性固定相 手性拆分 戊唑醇 |
| 文章编号： | 0251-0790（2007）02-0258-03 |
| 收稿时间： | 2006-03-23 |
| 修稿时间： | 2006-03-23 |
Enantiomeric Resolution of Tebuconazole on Immobilized Cellulose Chiral Stationary Phase |
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| MING Yong-Fei,ZHAO Liang,ZHANG Hong-Li,SHI Yan-Ping,LI Yong-Min.Enantiomeric Resolution of Tebuconazole on Immobilized Cellulose Chiral Stationary Phase[J].Chemical Research In Chinese Universities,2007,28(2):258-260. |
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| Authors: | MING Yong-Fei ZHAO Liang ZHANG Hong-Li SHI Yan-Ping LI Yong-Min |
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| Institution: | 1. Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 2. Graduate School of Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | The chiral stationary pahse of 3,5-dimethylphenylcarbamates of cellulose chemically bonded to 3-aminopropyl silica gel at the 6-position of the glucose units was prepared. The racemates of tebuconazole were resolved on the new immobilized chiral stationary phase, and the influences of modifiers(alcohols, THF and chloroform) in the mobile phase on the resolution were investigated. The chromatographic conditions were optimized. The results show that the new immobilized chiral stationary phase exhibits a good stereoselectivity to tebuconzole. The best resolution of 1.51 of tebuconazole was obtained by using hexane/2-propanol/ THF(volume ratio 90:5:5) as the mobile phase on a 150 mm column. |
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| Keywords: | Immobilization Chiral stationary phase Chiral resolution Tebuconazole |
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