An optimal response-adaptive design with dual constraints |
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Authors: | Atanu Biswas Rahul Bhattacharya |
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Institution: | 1. Applied Statistics Unit, Indian Statistical Institute, 203 B. T. Road, Kolkata–700 108, India;2. Department of Statistics, West Bengal State University, Barasat, Kolkata–700 126, India |
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Abstract: | The article deals with an optimal response-adaptive design for allocating patients among two competing treatments in a phase III clinical trial. An optimal response-adaptive target is developed for a general class of response distributions subject to two clinically relevant constraints. Various theoretical and numerical properties of the proposed procedure are investigated and compared with some existing competitors. A data study is also included for the assessment of the proposed procedure in real situation. |
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