| Chemical Studies on Decahydroacenaphthylene Compounds-Studies on the Synthesis of Hainanolide-Construction of Tricyclic Intermediate |
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| 作者姓名： | Zheng Qi YANG Shi Zhi CHEN Liang HUANG |
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| 作者单位： | Institute of Materia Medica，Chinese Academy of Medical Science，Peking Union Medical College，Beding 100050 |
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| 摘 要： | Underthenamesofharrigtonolideandhainanolide,(I)wasobtainedindependentlybyButalandSunZfromdifferentspieces.Itwasdemonstratedsignificalltamivirusandantitumoractivityinvitroandvivotest3.ThecomplicateandnoveltypeofstructurewouldbeagreatchallengetostUdyitstotalsynthesis.Itcanbeobtainedfromhainanolidol(II),theanalogueof(I)isolatedfromCHainannesisL.,byPh(OAc).'.Aretro-syntheticschemethroughatricycliccompound(ill)hasbeendesigned.Inordertoobtaintheintermediate(lll),asyntheticrouteseemedtobereason…
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Chemical Studies on Decahydroacenaphthylene Compounds-Studies on the Synthesis of Hainanolide-Construction of Tricyclic Intermediate |
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| Zheng Qi YANG, Shi Zhi CHEN, Liang HUANG,.Chemical Studies on Decahydroacenaphthylene Compounds-Studies on the Synthesis of Hainanolide-Construction of Tricyclic Intermediate[J].Chinese Chemical Letters,1998(3). |
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| Authors: | Zheng Qi YANG Shi Zhi CHEN Liang HUANG |
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| Abstract: | The tricyclic compound is constructed via intramolecular Diels-Alder reaction. It mightserve as the important intermediate for the total synthesis of hainanolide. The isolation andstructures of three by-products were also described. |
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| Keywords: | decahydroacenaphthylene intramolecular Diels-Alder reaction |
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