| 导数吸光光度法快速测定药物的体外经皮渗透量 |
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| 引用本文： | 赵志伟,于铁力.导数吸光光度法快速测定药物的体外经皮渗透量[J].理化检验(化学分册),2003,39(3):153-155. |
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| 作者姓名： | 赵志伟 于铁力 |
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| 作者单位： | 1. 天津医科大学,药学院,天津,300203
2. 吉林北华大学,医学院 |
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| 摘 要： | 用改进了的Franz扩散室（L.G.Y扩散室）处理给药贴片和鼠皮，设定取样时段，吸取接受室中溶液，用导数吸光光度法测定给药经皮渗透量。所得结果与高效液相色谱法（HPLC）一致，而效率约为原法（使用未改进的Fuanz扩散室，用HPLC测定）的10倍。
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| 关 键 词： | 导数吸光光度法 透皮吸收给药系统 TTS HPLC Franz扩散室 硝苯啶 |
| 文章编号： | 1001-4020(2003)03-0153-03 |
| 修稿时间： | 2001年12月29 |
DETERMINATION OF TRANSDERMAL DELIVERY OF DRUGS BY DERIVATIVE SPECTROPHOTOMETRY |
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| ZHAO Zhi-wei.DETERMINATION OF TRANSDERMAL DELIVERY OF DRUGS BY DERIVATIVE SPECTROPHOTOMETRY[J].Physical Testing and Chemical Analysis Part B:Chemical Analgsis,2003,39(3):153-155. |
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| Authors: | ZHAO Zhi-wei |
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| Abstract: | Transdermal delivery of drugs was determined by derivative spectrophotometry. The medicated patch piece and rat skin were treated with the improved Franz diffuser (L.G.Y. diffuser). A 5ml aliquot of the sample solution was taken at fixed time interval from the stripping cuvette and the amounts of transdermal delivery drug was determined by derivative spectrophotometry. The results obtained by the present method was found to be in consistency with those obtained by HPLC. The proposed method was also proved to be about 10 times more efficient than the HPLC method using ordinary Franz diffuser. |
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| Keywords: | Derivative spectrophotometry Transdermal therapeutic system HPLC Franz diffuser |
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