Direct chemoselective allylation of inert amide carbonyls |
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Authors: | Oda Yukiko Sato Takaaki Chida Noritaka |
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Affiliation: | Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Yokohama 223-8522, Japan. |
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Abstract: | Direct allylation of inert amide carbonyls utilizing the Schwartz reagent afforded either substituted tertiary or secondary amines. A preactivation step was successfully avoided, which is generally a requisite to increase the electrophilicity of amides. The reaction exhibited remarkable functional group tolerance and proceeded even in the presence of methyl esters and nitro groups. |
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