| Synthesis and antitumor activity of 6- and 2- （ 1-acyl sulfanylalkyl）-5,8-dimethoxy- 1,4-naphthoquinones |
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| 作者姓名： | Li Ming Zhao ;Tian Pei Xie ;YU Qin He ;De Feng Xu ;Shao Shun Li |
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| 作者单位： | a School of Pharmacy, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, China;b Shanghai Standard Biotech Co. Ltd., 1011 Halei Road, Shanghai 201203, China |
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| 摘 要： | Sixteen novel 6- and 2-（1-acylsulfanylalkyl）-5,8-dimethoxy-l,4-naphthoquinones were designed and synthesized. Their cytotoxicities were evaluated in vitro against BEL-7402, HT-29 and SPC-Al cell lines. The pharmacological results showed that most of the prepared compounds displayed the excellent selectivity for HT-29 cell line. Compound lab exhibited the most potent antitumor activity among the tested compounds.
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| 关 键 词： | 5 8-二甲氧-l 4-萘醌 合成作用 抗癌作用 化学分析 |
Synthesis and antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones |
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| Li Ming Zhao,;Tian Pei Xie,;YU Qin He,;De Feng Xu,;Shao Shun Li.Synthesis and antitumor activity of 6-and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones[J].Chinese Chemical Letters,2008,19(10):1206-1208. |
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| Authors: | Li Ming Zhao Tian Pei Xie Yu Qin He De Feng Xu Shao Shun Li |
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| Institution: | a School of Pharmacy, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, China;b Shanghai Standard Biotech Co. Ltd., 1011 Halei Road, Shanghai 201203, China |
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| Abstract: | Sixteen novel 6-and 2-(1-aeylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones were designed and synthesized.Their eytotoxicifies were evaluated in vitro against BEL-7402,HT-29 and SPC-Al cell lines.The pharmacological results showed that most of the prepared compounds displayed the excellent selectivity for HT-29 cell line.Compound 16b exhibited the most potent antitumor activity among the tested compounds. |
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| Keywords: | 5 8-Dimethoxy-1 4-naphthoquinone derivatives Synthesis Antimmor activity |
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