| 双乙酰二茂铁缩肼基二硫代甲酸甲酯Schiff碱的合成、晶体结构和生物活性(英文) |
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| 引用本文： | 杨敏,贺红举,李彦克,李明雪.双乙酰二茂铁缩肼基二硫代甲酸甲酯Schiff碱的合成、晶体结构和生物活性(英文)[J].化学研究,2012,23(3):76-81. |
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| 作者姓名： | 杨敏 贺红举 李彦克 李明雪 |
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| 作者单位： | 1. 河南大学化学化工学院,河南开封,475004
2. 河南化学工业技师学院,河南开封,475002 |
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| 基金项目： | Project of National Natural Science Foundation of China(21071043) |
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| 摘 要： | 用双乙酰二茂铁和肼基二硫代甲酸甲酯为起始原料,制备了含二茂铁的Schiff碱配体(CH3)SSCNHN=C(CH3)(C5H4)]2Fe.利用元素分析以及红外光谱和单晶X射线衍射分析了产物的组成、化学特征及晶体结构,并测定了其生物活性.结果表明,标题化合物对Ec9706食管癌细胞株具有适度的生长抑制活性.
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| 关 键 词： | 二茂铁 肼基二硫代甲酸甲酯 Schiff碱 合成 晶体结构 生物活性 |
Synthesis, crystal structure and biological activity of diacetylferrocene-S-methyldithiocarbazate Schiff-base |
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| YANG Min
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HE Hong-ju
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LI Yan-ke
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LI Ming-xue.Synthesis, crystal structure and biological activity of diacetylferrocene-S-methyldithiocarbazate Schiff-base[J].Chemical Research,2012,23(3):76-81. |
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| Authors: | YANG Min HE Hong-ju LI Yan-ke LI Ming-xue |
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| Institution: | 1College of Chemistry and Chemical Engineering, Henan University, Kai feng 475004, Henan, China; 2. Henan Senior Technician School of Chemical Industry, Kai f eng 475002, Henan , China) |
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| Abstract: | A ferrocene-containing Schiff-base ligand, （CH3 ）SSCNHN= C（CHa ） （C5 H4 ）]2 Fe, was synthesized by using diacetylferrocene and S-methyldithiocarbazate as the starting materials. The composition, chemical feature and crystal structure of as-synthesized product were analyzed by means of elemental analysis, infrared spectrometry and single-crystal X-ray diffraction; and its biological activity was evaluated. Results indicate that the title compound exhibits moderate anticancer activity in the cell growth inhibition of the Ec9706 human oesophagus cancer cell line. |
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| Keywords: | ferrocene S-methyldithiocarbazate Schiff-base synthesis crystal structure biological activity |
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