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Cyclic tetrapeptides bearing a sulfhydryl group potently inhibit histone deacetylases |
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| Authors: | Nishino Norikazu Jose Binoy Okamura Shinji Ebisusaki Shutoku Kato Tamaki Sumida Yuko Yoshida Minoru |
| Institution: | Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, Japan. nishino@life.kyutech.ac.jp |
| Abstract: | New inhibitors of histone deacetylase (HDAC) containing a sulfhydryl group were designed on the basis of the corresponding hydroxamic acid (CHAP31) and FK228. Their disulfide dimers and hybrids exhibited potent HDAC inhibitory activity in vivo with potential as anticancer prodrugs. structure: see text] |
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