Vaccination of mice against Leishmania mexicana amazonensis with microsomal fraction associated with BCG |
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| Affiliation: | 1. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China;2. State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China;3. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China;4. College of Animal Husbandry and Veterinary Medicine, Jinzhou Medical University, Jinzhou, Liaoning Province 121001, PR China;5. Changchun Key Laboratory of Transomics Biotechnologies, GenSci-Changchun, Changchun, Jilin Province 130600, PR China;6. College of Basic Medicine, Mudanjiang Medical College, Mudanjiang, Heilongjiang Province 157011, PR China;1. College of Marine Science, Shandong University at Weihai, Weihai, Shandong Province 264209, PR China;2. College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province 130118, PR China;3. Jilin Entry-Exit Inspection and Quarantine Bureau, ChangChun, Jilin Province 130000, PR China;1. Institute of Molecular Medicine, New Delhi India;2. Department of Research, Sir Gangaram Hospital, New Delhi, India |
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| Abstract: | Attempts to develop a satisfactory vaccine against New World cutaneous leishmaniasis have been made with varying success. We found that in mice, pretreated subcutaneously with 2×106 BCG organisms 2 weeks prior to immunization at the same site with as low as 10 μg of a microsomal preparation (Pol-F) of Leishmania mexicana amazonensis, a profound alteration was observed in the course of infection produced by inoculation of virulent amastigotes of the same strain. The BCG-Pol-F vaccine preparation was consistently shown to have a protective capacity associated with larger classical cellular immune response (skin test) and higher specific antibody titres in response to leishmanial challenge dose (1 × 106 amastigotes/mouse). |
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