Nuclear location of the p55 subunit of the IL-2 receptor following activation of the HT-2 T helper cell line |
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| Institution: | 1. Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, China;2. Department of Pharmacology, Shandong college of Traditional Chinese Medicine, 508 East Binhai road, Yantai 264199, China;3. Key Laboratory of Chemical Biology of Natural Products, Ministry of Education, Shandong University, Jinan, China;1. School of Materials Science and Engineering, Central South University, Changsha 410083, China;2. Light Alloy Research Institute, Central South University, Changsha 410083, China;3. China Electric Power Research Institute, Wuhan 430074, China |
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| Abstract: | After mitogenic or antigenic stimulation, T cells express interleukin-2 receptors (IL-2R). The mechanism and control of signal transduction following binding of IL-2 to IL-2R are poorly understood.Using two rat monoclonal antibodies (5A2 and 7D4) specific for two distinct epitopes of the p55 subunit of mouse IL-2R, we have studied the cellular localization of this molecule by immunocytochemistry during the IL-2-mediated activation of mouse T helper cell clone HT-2. During the activation cycle, nuclear staining for the p55 subunit of the IL-2 receptor was transiently observed. It is suggested that the transient nuclear location of the IL-2R may play a critical role in the control of T-cell activation, proliferation and/or differentiation. |
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