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Preparation and characterization of finely dispersed drugs. 5. Ethyl 3,5-di(acetylamino)-2,4,6-triiodobenzoate
Authors:H. William Bosch   Sre   o D. &#x  kapin  Egon Matijevi&#x
Affiliation:

aélan Drug Delivery Inc., 3500 Horizon Drive, King of Prussia, PA 19406, USA

bCenter for Advanced Materials Processing, Clarkson University, Potsdam, NY 13699-5814, USA

Abstract:Controlled precipitation of the diagnostic imaging agent ethyl 3,5-di(acetylamino)-2,4,6-triiodobenzoate has been used to produce fine particles of various sizes, morphologies, and degrees of crystallinity, which depended on experimental conditions. In addition, two distinct polymorphic forms of the drug have been fully characterized by single crystal X-ray diffraction studies, and evidence for a third polymorph was also observed. Some of the so prepared dry particles were coated with a thin layer of silica.
Keywords:Ethyl 3,5-di(acetylamino)-2,4,6-triiodobenzoate   X-ray diffraction studies   Silica
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