Synthesis and Cytotoxicity of Derivatives of Di(3-indolyl) Selenide |
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| Authors: | E. Abele J. Popelis I. Shestakova I. Domracheva P. Arsenyan E. Lukevics |
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| Affiliation: | (1) Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia |
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| Abstract: | A method has been developed for the synthesis of di(3-indolyl) selenides. From indole and SeO2. N-Alkyl derivatives of di(3-indolyl) selenide have been obtained in the two-phase system alkyl halide–solid K2CO3 (or KOH)–18-crown-6–toluene. It was discovered that N-unsubstituted di(3-indolyl) selenides possess high cytotoxicity on HT-1080 and MG-22A tumor cell lines. |
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| Keywords: | indole selenides phase-transfer catalysis cytotoxicity |
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