Palladium-catalyzed silyl C(sp3)-H bond activation |
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Authors: | Liang Yun Geng Weizhi Wei Junnian Ouyang Kunbing Xi Zhenfeng |
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Affiliation: | Beijing National Laboratory for Molecular Sciences, College of Chemistry, Peking University, Beijing, 100871, China. |
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Abstract: | The first transition-metal-catalyzed activation of silyl C(sp(3))-H bond was realized and synthetically applied. A variety of organic skeletons substituted with SiMe(3) groups could undergo the Pd-catalyzed intramolecular coupling reaction, resulting in an unprecedented synthetic method for yielding six-membered silacycles. It was found that the adjacent Si atom played an essential role for the activation of the C(sp(3))-H bond of the SiMe(3) group; no activation reaction of the C(sp(3))-H bond of the CMe(3) group took place under the same reaction conditions. |
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