| 药典级DL-苹果酸的合成及精制工艺 |
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| 引用本文： | 蒋俊杰,潘春,张俊鹏,尹文浩,张晓萍.药典级DL-苹果酸的合成及精制工艺[J].合成化学,2002,10(3):224-227. |
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| 作者姓名： | 蒋俊杰 潘春 张俊鹏 尹文浩 张晓萍 |
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| 作者单位： | 1. 江苏省生化手性工程技术研究中心,江苏,常州,213033;常茂生物化学工程股份有限公司,江苏,常州,213016
2. 常茂生物化学工程股份有限公司,江苏,常州,213016 |
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| 摘 要： | 采用正交设计试验研究了药典级DL－苹果酸的合成工艺。考察了反应物配料浓度、反应时间、反应温度等因素对转化率及选择性的影响。优化了合成工艺及精制方法，解决了达到药典级产品纯化的难题。
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| 关 键 词： | DL－苹果酸 合成 精制工艺 正交设计 医药产品 |
| 文章编号： | 1005-1511(2002)03-224-04 |
| 修稿时间： | 2002年3月13日 |
Synthesis and Purification of Pharmacopoeia Grade DL-malic Acid |
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| JIANG Jun-jie ,PAN Cun ,ZHANG Jun-peng ,YIN Wen-hao ,ZHANG Xiao-ping.Synthesis and Purification of Pharmacopoeia Grade DL-malic Acid[J].Chinese Journal of Synthetic Chemistry,2002,10(3):224-227. |
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| Authors: | JIANG Jun-jie PAN Cun ZHANG Jun-peng YIN Wen-hao ZHANG Xiao-ping |
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| Institution: | JIANG Jun-jie 1,2,PAN Cun 1,2,ZHANG Jun-peng 2,YIN Wen-hao 2,ZHANG Xiao-ping 1,2 |
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| Abstract: | The synthetic technique of pharmacopoeia grade DL-malic acid through orthogonal test was studied. The effects of reaction temperature, material mol ratio, reaction time and other factors on the conversion ratio were tested. The results showed that the reaction temperature, material mol ratio, and reaction time have respectively great effects on the conversion ratio. The synthetic and purification techniques were optimized to produce the pharmacopoeia grade DL-malic acid.. |
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| Keywords: | malic acid synthesis purification orthogonal test |
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