Michael addition-elimination reactions of chiral enolates with ethyl 3-halopropenoates |
| |
Authors: | Esteban Jorge Costa Anna M Gómez Alex Vilarrasa Jaume |
| |
Affiliation: | Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, Av. Diagonal 647, 08028 Barcelona, Catalonia, Spain. |
| |
Abstract: | Key dienoic or dienal substructures of cytotoxic macrolides amphidinolide E and dictyostatin have been prepared via a Michael addition (followed by elimination of X-) of chiral enolates on beta-halo derivatives of ethyl acrylate, with full retention of the initial E or Z configuration. Evans oxazolidin-2-ones and our related thiazolidin-2-ones, as well as a fine-tuning of the reaction conditions, have been essential. Many chiral building blocks are accessible from these adducts. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|