Application of stereological methods to estimate post-mortem brain surface area using 3 T MRI |
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| Authors: | Carolyn Furlong Marta García-Fiñana Michael Puddephat Anna Anderson Katrine Fabricius Nina Eriksen Bente Pakkenberg Neil Roberts |
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| Institution: | 1. Magnetic Resonance and Image Analysis Research Centre (MARIARC), University of Liverpool, UK;2. Department of Biostatistics, University of Liverpool, UK;3. Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen, Denmark;4. Clinical Research Imaging Centre (CRIC), College of Medicine and Veterinary Medicine, University of Edinburgh, UK |
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| Abstract: | The Cavalieri and Vertical Sections methods of design based stereology were applied in combination with 3 tesla (i.e. 3 T) Magnetic Resonance Imaging (MRI) to estimate cortical and subcortical volume, area of the pial surface, area of the grey–white matter boundary, and thickness of the cerebral cortex. The material comprises eight human cadaveric cerebri which had been separated into sixteen cerebral hemisphere specimens prior to embedding in agar gel. The results from MRI were compared with corresponding ‘gold standard’ values subsequently obtained by application of the same methodology using physical sectioning of the specimens. |
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| Keywords: | Cavalieri method MRI Post-mortem brain Stereology Surface area Vertical Sections Volume |
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