Comparison between multi-echo T2* with and without fat saturation pulse for quantification of liver iron overload |
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Authors: | Liana Sanches-Rocha Bruna Serpa Eduardo Figueiredo Nelson Hamerschlak Ronaldo Baroni |
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Affiliation: | 1. Department of Imaging (MRI), Hospital Israelita Albert Einstein, 627, Albert Einstein Avenue, 1o.SS Bl.B 05652-900 São Paulo, Brazil;2. Department of Imaging, Hospital Israelita Albert Einstein, R. Presidente Coutinho 297, AP 302 B 88015-230 Florianópolis SC, Brazil;3. MR Advanced Applications-Research Latin America, GE Healthcare-Brazil, Av. das Nações Unidas, 8501 3rd floor Pinheiros, 05425-070 São Paulo-SP, Brazil;4. Hematology and Bone Marrow Transplant Department, Hospital Israelita Albert Einstein, 627, Albert Einstein Avenue, 2o.SS Bl.B, 05652-900 São Paulo, Brazil;5. Department of Imaging (MRI), Hospital Israelita Albert Einstein, 627, Albert Einstein Avenue, 4th Bl.D, 05652-900 São Paulo, Brazil |
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Abstract: | PurposeTo test a magnetic resonance image (MRI) technique that uses an additional pulse in multi-echo T2* sequence that works to suppress the fat signal, in subjects with liver iron overload and concomitant presence of fat in the liver, which have been revealed as a major drawback that compromises the correct iron quantification by MRI.Materials and MethodsFifty magnetic resonance images of the liver (1.5 T scanner) of individuals with blood ferritin increases were retrospectively reviewed for the presence of steatosis, using the sequence in and out of phase, and iron overloading, using two sequences T2 * multi-echo: one standard and other with additional fat suppression pulse. T2 * values and their standard deviations were analyzed statistically.ResultsOur results showed that a significantly lower standard deviation of T2* values is obtained when the fat saturation pulse is applied in patients with steatosis. We found that modulation of fat signal on liver iron overload resulted in a different categorization of some patients. In one case, the patient was re-classified within normal levels of liver iron.ConclusionOur findings may contribute to a better measure of liver iron overload with relevant implications for patient treatment and care. |
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Keywords: | Magnetic resonance imaging Fatty liver Iron overload |
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