Neurofibrillary tangles and plaques are not accompanied by white matter pathology in aged triple transgenic-Alzheimer disease mice |
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Authors: | Marzena Z. Kastyak-Ibrahim Domenico L. Di Curzio Richard Buist Sheryl L. Herrera Benedict C. Albensi Marc R. Del Bigio Melanie Martin |
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Affiliation: | 1. Department of Physics, University of Winnipeg, 515 Portage Avenue, Winnipeg, Manitoba, R3B 2E9, Canada;2. Department of Human Anatomy & Cell Science, University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada;3. Department of Radiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada;4. Department of Physics, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada;5. Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada;6. Department of Pathology, University of Manitoba, Winnipeg, Manitoba, R3E 0W3, Canada |
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Abstract: | Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is the most common cause of dementia in aging populations. Although senile plaques and neurofibrillary tangles are well-established hallmarks of AD, changes in cerebral white matter correlate with cognitive decline and may increase the risk of the development of dementia. We used the triple transgenic (3xTg)-AD mouse model of AD, previously used to show that white matter changes precede plaque formation, to test the hypothesis that MRI detectable changes occur in the corpus callosum, external capsule and the fornix. T2-weighted and diffusion tensor magnetic resonance imaging and histological stains were employed to assess white matter in older (11–17 months) 3xTg-AD mice and controls. We found no statistically significant changes in white matter between 3xTg-AD mice and controls, despite well-developed neurofibrillary tangles and beta amyloid immunoreactive plaques. Myelin staining was normal in affected mice. These data suggest that the 3xTg-AD mouse model does not develop MRI detectable white matter changes at the ages we examined. |
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Keywords: | Alzheimer's disease Mouse Magnetic resonance imaging Diffusion tensor imaging White matter 3xTg-AD |
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