Gd complexes of diethylenetriaminepentaacetic acid conjugates of low-molecular-weight chitosan oligosaccharide as a new liver-specific MRI contrast agent |
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Authors: | Yan Huang Bennan Cao Xiaolu Yang Qi Zhang Xiangjun Han Ziyi Guo |
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Affiliation: | 1. School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, China;2. Hainan Provincial Key Lab of Fine Chemistry, Hainan University, Haikou, Hainan, 570228, China;3. School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, China;4. Radiology Department Hospital Municipal of Haikou, Haikou, Hainan, 570208, China |
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Abstract: | This study was to describe the synthesis of complexes of gadolinium diethylenetriaminepentaacetic acid conjugates of low-molecular-weight chitosan oligosaccharide Gd-DTPA-CSn (n = 6, 8, 11) as a new class of contrast agent as well as its magnetic property in a pilot magnetic resonance imaging. The efficacy of the contrast agent was assessed by measuring the longitudinal relaxivity (r1), FLASH imaging in phantoms in vitro and signal intensity in vivo of the rat abdominal axial imaging. The r1 of Gd-DTPA-CS11 was up to 11.65 mM− 1·s− 1, which was 3 times higher than that of the analogous MRI contrast agent Gd-DTPA in commercial use. In vivo MR images of rat obtained with Gd-DTPA-CS11 showed strong signal enhancement in liver and the vessels of the liver parenchyma during the extended period of time. The present study suggests that the new synthesized gadolinium complexes can be used as a new class of practical liver-specific MRI contrast agent because of its superior performance compared with Gd-DTPA. |
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Keywords: | Magnetic resonance imaging Contrast agent Chitosan oligosaccharide Relaxivity Liver-specific |
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