| Catalytic asymmetric borane reduction of prochiral ketones using chiral camphor-derived mercapto-alcohols |
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| 作者姓名： | 周永贵 侯雪龙 戴立信 |
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| 作者单位： | Laboratory of Organometallic Chemistry，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Laboratory of Organometallic Chemistry，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China，Laboratory of Organometallic Chemistry，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China (29790127) and Chinese Academy of Sciences. |
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| 摘 要： | Easily available D-(+)-camphor-derived chiral mercapto-alcohols 2 and 3 were employed for catalytic asymmetric borane reduction of aromatic ketones. Moderate enantioselectivities with e.e. 20.2-72.1% were obtained with 10 mol% catalyst. Opposite asymmetric induction was achieved when mercapto-alcohols 2 and 3 were used.
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Catalytic asymmetric borane reduction of prochiral ketones using chiral camphor-derived mercapto-alcohols |
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| ZHOU,Yong-Gui HOU,Xue-Long DAI,Li-XinLaboratory of Organometallic Chemistry.Catalytic asymmetric borane reduction of prochiral ketones using chiral camphor-derived mercapto-alcohols[J].Chinese Journal of Chemistry,1998,16(3):284-288. |
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| Authors: | ZHOU Yong-Gui HOU Xue-Long DAI Li-XinLaboratory of Organometallic Chemistry |
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| Institution: | ZHOU,Yong-Gui HOU,Xue-Long DAI,Li-XinLaboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China |
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| Abstract: | Easily available D-(+)-camphor-derived chiral mercapto-alcohols 2 and 3 were employed for catalytic asymmetric borane reduction of aromatic ketones. Moderate enantioselectivities with e.e. 20.2-72.1% were obtained with 10 mol% catalyst. Opposite asymmetric induction was achieved when mercapto-alcohols 2 and 3 were used. |
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| Keywords: | Mercapto-alcohol ketone asymmetric borane reduction |
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