Simultaneous determination of tetrathiomolybdates and molybdates in spiked blood plasma by differential pulse voltammetry and their speciation |
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| Authors: | Stella T. Giroussi A. N. Voulgaropoulos Aristomenis Ayiannidis |
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| Affiliation: | (1) Postgraduate student, scholarship holder of Greek State Scholarship Foundation Analytical Chemistry Laboratory, Department of Chemistry, Aristotle University of Thessaloniki, GR-54006 Thessaloniki, Greece;(2) Analytical Chemistry Laboratory, Department of Chemistry, Aristotle University of Thessaloniki, GR-54006 Thessaloniki, Greece;(3) Chemistry Laboratory, Veterinary Faculty, Aristotle University of Thessaloniki, GR-54006 Thessaloniki, Greece |
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| Abstract: | A selective, sensitive and reliable voltam- metric method for the simultaneous determination of MoS2-4 and MoO2-4 has been developed. The reduction of HgMoS4 at –0.43 V and the reduction of Mo as complex of MoO2-oxine2 at –0.63 V in acetate buffer at pH 4.9 are utilized for the simultaneous determination by differential pulse cathodic stripping voltametry (DPCSV). Cadmium and lead form complexes with MoS2-4, but do not interfere with the determination. The limit of detection is 0.59  g/l Mo for MoS2-4 and 1.8 g/l Mo for MoO2-4. The R.S.D at a concentration level of 20 g/l is 4.7% for MoO2-4 and 3.6% for MoS2-4. The method is applied to spiked blood plasma samples for the determination of free tetrathiomolybdates and molybdates. Additionally, labile tetrathiomolybdates and molybdates can be determined in spiked blood plasma after treatment of the sample with 0.15 mol/l KCN and ultrafiltration. |
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