Synthesis and antituberculotic activity of some new imidazo[4,5-b]pyridine derivatives |
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| Authors: | L. Bukowski Z. Zwolska E. Augustynowicz-Kopec |
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| Affiliation: | (1) Department of Organic Chemistry, Medical University of Gdansk, 80-416 Gdansk, Poland;(2) Department of Microbiology, Institute of Tuberculosis and Pulmonary Diseases, 01-138 Warszawa, Poland |
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| Abstract: | The reactions of 2-acetylimidazo[4,5-b]pyridine hydrazone with some alkyl-and arylisothiocyanates and some orthoesters were carried out. Various new derivatives of the titled compound such as thiosemicarbazones, ethoxymethylenehydrazones, and derivatives of the new pyrido-[3′,2′:4,5]imidazo[1,2-d][1,2,4]triazine ring system were obtained. Biological data for selected compounds are presented. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1571–1579, October, 2006. |
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| Keywords: | hydrazones imidazo[4,5-b]pyridine pyrido[3′ ,2′ :4,5]imidazo[1,2-d][1,2,4]triazine thiosemicarbazones antituberculotic activity |
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