First efficient synthesis of novel oxophenyl-arcyriaflavin analogs |
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Authors: | Aurélie Bourderioux Valérie Bénéteau Jean-Yves Mérour |
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Institution: | Institut de Chimie Organique et Analytique, Université d’Orléans, UMR CNRS 6005, rue de Chartres, B.P. 6759, 45067 Orléans Cedex 2, France |
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Abstract: | New oxophenylarcyriaflavins were synthesized in a few efficient steps. The key steps involved at first a palladium cross-coupling between the 3-bromo-4-(1H-indol-3-yl)1-methylpyrrole-2,5-dione and the 2-formylphenylboronic acid or a methyl 2-trialkylstannylbenzoate, followed by an intramolecular acylation in a C-2 indolic position. All the sequence was carried out without any indolic protective group. |
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Keywords: | Anticancer agents Indolocarbazoles synthesis Arcyriaflavin |
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