Synthesis of the NO ring model of gymnocin-B |
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| Authors: | Chihiro Tsukano |
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| Affiliation: | Graduate School of Life Sciences, Tohoku University, Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan |
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| Abstract: | A synthetic route to the NO ring model of gymnocin-B, a cytotoxic marine polycyclic ether with the largest contiguous rings, has been achieved. The synthesis features construction of the seven-membered O ring with 1,3-dimethyl substituents flanking the ether oxygen by ring-closing metathesis. |
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