Claisen self-condensation/decarboxylation as the key steps in the synthesis of C2-symmetrical 1,7-dioxaspiro[5.5]undecanes |
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| Authors: | Bas Lastdrager |
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| Affiliation: | Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands |
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| Abstract: | A convenient method for the synthesis of functionalised 1,7-dioxaspiro[5.5]undecanes using acid-catalysed spiroketalisations of substituted dihydroxyketones is described. The dihydroxyketones were readily prepared from appropriately substituted hydroxy esters via Claisen self-condensation followed by decarboxylation. |
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