Direct mono-phosphorylation of 1,3-diols. A synthesis of FTY720-phosphate |
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| Authors: | Shuzo Takeda Masao Chino Masatoshi Kiuchi Kunitomo Adachi |
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| Affiliation: | Research Laboratory III (Immunology), Mitsubishi Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0033, Japan |
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| Abstract: | A novel method for selective and direct phosphorylation of various 1,3-diols using silver(I) oxide, tetrabenzyl pyrophosphate (TBPP), and tetrahexylammonium iodide affording mono-phosphates was developed. We applied the present method to the synthesis of FTY720-phosphate. |
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| Keywords: | FTY720 Mono-phosphorylation 1,3-diol Silver(I) oxide Tetrabenzyl pyrophosphate (TBPP) Tetrahexylammonium iodide |
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