Traceless liquid-phase synthesis of 3-alkylamino-4,5-disubstituted-1,2,4-triazoles on polyethylene glycol (PEG) |
| |
| Authors: | Ying-Xiao Zong Guo-Ren Yue Lei Feng Zheng-En Song Hai Song Yu-Qi Han |
| |
| Institution: | Key Laboratory of Resources and Environment, Chemistry of West China, Department of Chemistry, Hexi University, Zhangye 734000, PR China |
| |
| Abstract: | A liquid-phase route to 3-alkylamino-4,5-disubstituted-1,2,4-triazoles has been developed, which permits the incorporation of three elements of diversity. The heterocycle was constructed upon PEG6000 (soluble polymer) modified by 4-hydroxy-2-methoxybenzaldehyde, from which a traceless cleavage could be realized with TFA/CH2Cl2. This method provided a library of 3-alkylamino-4,5-disubstituted-1,2,4-triazoles with reasonable yields and excellent purity. |
| |
| Keywords: | Poly(ethylene glycol) (PEG) 3-Alkylamino-4 5-disubstituted-1 2 4-triazoles Arylacyl thiourea Benzoyl hydrazine Liquid-phase synthesis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
