Facile syntheses of conformationally constrained analogues of lysine and homoglutamic acid |
| |
Authors: | Salim Barkallah |
| |
Institution: | Department of Biochemistry and Biophysics and the Johnson Research Foundation, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6059, USA |
| |
Abstract: | A facile divergent synthesis of the novel amino acid trans-4-aminoethyl-l-proline and trans-4-carboxymethyl-l-proline from commercially available trans-4-hydroxy-l-proline was developed. These conformationally constrained analogues of l-lysine and l-homoglutamic acid are useful proline templated amino acids (PTAAs) with potential applications in protein engineering and de novo protein design. |
| |
Keywords: | Aminoethyl Proline Carboxymethyl Amino acid Polyproline |
本文献已被 ScienceDirect 等数据库收录! |