Aspects of investigating scrambling in the synthesis of porphyrins: different analytical methods |
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Authors: | Christian B Nielsen Frederik C Krebs |
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Institution: | Polymer Department, Risø National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde, Denmark |
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Abstract: | Herein, we discuss the analyses and quantification of the different components in porphyrin mixtures, prepared from p-anisaldehyde, p-tolualdehyde, and 5-(4-bromophenyl)-dipyrromethane with acid catalysis, using NMR and HPLC. The advantages and disadvantages of these analytical methods are emphasized. Due to the similar size of a bromine atom and a methyl group it was possible to grow crystals suitable for X-ray crystallographic studies from a mixture of porphyrins, where the 4-position of the meso-phenyl rings was either substituted with methyl groups or bromine atoms. We also show that X-ray studies are inferior to NMR analysis for determining the components in a porphyrin mixture. |
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Keywords: | Analysis of porphyrin mixtures Analytical techniques NMR HPLC X-ray crystallography |
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