The expedient access to bromo-pyridine carbaldehyde scaffolds using gem-dibromomethyl intermediates |
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| Authors: | Ashis Baran Mandal Anna Quattropani |
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| Affiliation: | a Syngene International Private Limited, 20th KM Hosur Road, Electronic City PO, Bangalore 560 100, India
b Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, 1228 Plan-les-Ouates, Geneva, Switzerland |
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| Abstract: | A simple, efficient, and general two-step synthesis to bromo-pyridine carbaldehyde scaffolds is described. This direct route involves sequential reactions employing the dibromination of bromo-picolines followed by hydrolysis using an aqueous solution of calcium carbonate. Bromo-pyridine carbaldehyde scaffolds 1-7 were obtained in good overall yield. Bromo-dibromomethyl-pyridine intermediates have been isolated and characterized. |
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| Keywords: | Picoline Pyridine carbaldehydes Dibromomethyl Hydrolysis Scaffolds |
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