Synthesis of spirooxindoles via asymmetric 1,3-dipolar cycloaddition |
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| Authors: | Ke Ding Jeffrey R Deschamps Shaomeng Wang |
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| Institution: | a Departments of Internal Medicine and Medicinal Chemistry and Comprehensive Cancer Center, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0934, USA
b The Laboratory for the Structure of Matter, Naval Research Laboratory, Washington, DC 20375, USA |
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| Abstract: | An efficient method was developed for the asymmetric synthesis of 2′-alkyl-4′aryl-1H-spiroindole-3,3′-pyrrolidin]-2-ones, which are potential inhibitors of the p53-MDM2 interaction. Our X-ray crystallographic analysis revealed that this 1,3-dipolar cycloaddition proceeds with high stereoselectivity but differently from previously published results. |
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| Keywords: | Spirooxindoles Asymmetric 1 3-dipolar cycloaddition Inhibitors of the p53-MDM2 interaction |
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