Iodine as a novel and efficient reagent for the synthesis of α-aminonitriles by a three-component condensation of carbonyl compounds, amines, and trimethylsilyl cyanide |
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| Authors: | Laurel Royer Richard A Gibbs |
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| Institution: | Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA |
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| Abstract: | A straightforward and general method has been developed for the synthesis of α-aminonitriles by simply combining aldehydes or ketones, amines, and trimethylsilyl cyanides in the presence of a catalytic amount of molecular iodine at room temperature. |
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| Keywords: | Aldehydes Ketones Amines Trimethylsilyl cyanide α-Aminonitriles Iodine |
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