Ionic liquids/H2O systems for the reaction of epoxides with NaN3: a new protocol for the synthesis of 2-azidoalcohols |
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| Authors: | JS Yadav BVS Reddy B Jyothirmai MSR Murty |
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| Institution: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | Oxiranes undergo ring opening rapidly with sodium azide in a bmim]BF4/H2O or bmim]PF6/H2O (2:1) solvent system, under mild and neutral reaction conditions to afford the corresponding 2-azidoalcohols in high to quantitative yields. The remarkable features of this procedure are improved yields, enhanced reaction rates, high regioselectivity and ease of recyclability of ionic liquids (ILs). The recovered ionic liquid can be reused for four to five times but with gradual decrease in activity. |
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| Keywords: | Ionic liquids (ILs) Oxiranes Azidoalcohols |
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