Synthesis of dysiherbaine analogue |
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| Authors: | Muneo Shoji Masato Oikawa Makoto Sasaki |
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| Institution: | a Graduate School of Life Sciences, Tohoku University, Tsutsumidori-amamiya, Aoba-ku, Sendai 981-8555, Japan
b School of Fisheries Science, Kitasato University, Sanriku-cho, Iwate 022-0100, Japan |
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| Abstract: | Synthesis of dysiherbaine analogue 4, which corresponds to 8,9-epi-neodysiherbaine A, is described. The synthesis features a concise route to the bicyclic ether skeleton through stereoselective C-glycosylation to set the C6 stereocenter and 5-exo ring-closure to form the tetrahydrofuran ring. The results of preliminary biological studies of 4 are also provided. |
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