An unusual solvent effect in the cuprate displacement reaction of indolizidin-5-yl-methyl p-toluenesulfonate: stereoselective synthesis of indolizidine alkaloids |
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| Authors: | P Ganapati Reddy |
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| Institution: | Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India |
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| Abstract: | An unusual solvent effect in the cuprate displacement reaction of indolizidin-5-yl-methyl p-toluenesulfonate with dialkyl cuprates, derived from an alkyllithium and Grignard reagents, during the synthesis of indolizidine alkaloids 167B and 209D is described. |
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| Keywords: | Cuprate displacement Solvent effect Stereoselective Indolizidine alkaloids Nucleophilic substitution |
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