A simpler and greener protocol for the preparation of β-acetylamino ketones by a one-pot reaction of aryl aldehydes, enolisable ketones, acetyl chloride and acetonitrile in the presence of zeolite Hβ as a reusable catalyst |
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| Authors: | Ramakrishna P. Bhat |
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| Affiliation: | Organic Chemistry Research Laboratory, Department of Chemistry, University Institute of Chemical Technology, N. M. Parekh Marg, Matunga, Mumbai 400 019, India |
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| Abstract: | β-Acetylamino ketones have been obtained in a one-pot coupling of an aldehyde with an enolisable ketone, acetyl chloride and acetonitrile in the presence of zeolite Hβ as catalyst at room temperature (26-28 °C). The procedure has the advantages of mild workup, circumvention of high temperature and inert atmosphere. The catalyst was found to be recyclable. |
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| Keywords: | β-Acetylamino ketones Multicomponent reaction Hβ catalyst One-pot synthesis |
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