The furan approach to oxacycles. Part 5: Synthesis of a chiral butenolide, building block towards biologically interesting natural products |
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| Authors: | Marta Teijeira |
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| Institution: | Departamento de Química Orgánica, Facultad de Química, Universidad de Vigo, 36200 Vigo, Spain |
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| Abstract: | We describe an efficient new approach for the synthesis of a chiral butenolide that is based on the oxidation of a chiral furan ring with singlet oxygen in the presence of Hünig’s base, followed by Luche reduction and in situ lactonization. |
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| Keywords: | Butenolide Singlet oxygen Michael addition Oxacycles Natural products |
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