Mild alkaline hydrolysis of some 7-O-flavone glycosides. Application to a novel access to rutinose heptaacetate |
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Authors: | Jé rô me Quintin |
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Affiliation: | Laboratoire de Pharmacognosie (BIOCIS, UPRES-A 8076 CNRS), Faculté de Pharmacie, av. J.B. Clément, 92296 Châtenay-Malabry Cedex, France |
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Abstract: | Alkaline hydrolysis of some 7-O-flavone glycosides was performed through the 6,8-dibromo derivative. When the sugar linked to the aglycon has a 2-hydroxy group trans to the sugar-aglycon bond as in β-D-glucosides or rutinosides, hydrolysis occurred at room temperature under very mild conditions. Application to a novel preparation of rutinose heptaacetate by hydrolysis of a diosmin derivative is described. |
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Keywords: | Flavone glycosides Flavonoids Diosmin Rutinose Bromination Alkaline hydrolysis Glycosidic bond |
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