Fluorous 2-chloropyridinium salt (Mukaiyama condensation reagent) for amide formation reactions |
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| Authors: | Tadamichi Nagashima Yimin Lu Michael J. Petro Wei Zhang |
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| Affiliation: | Discovery Chemistry, Fluorous Technologies Inc., University of Pittsburgh, Applied Research Center, 970 William Pitt Way, Pittsburgh, PA 15238, USA |
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| Abstract: | A new fluorous 2-chloropyridinium hexafluorophosphate was prepared as a modified Mukaiyama condensation reagent, and it was applied in amide formation reactions. Good to excellent purities of amides were obtained after fluorous solid-phase extraction of reaction mixtures without additional chromatography. |
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| Keywords: | Fluorous reagent Amide coupling Fluorous solid-phase extraction |
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