The preparation of 1,2,4-triazines from α,β-diketo-ester equivalents and their application in pyridine synthesis |
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| Authors: | Marta Altuna-Urquijo Brian Tarbit |
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| Affiliation: | a School of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
b Seal Sands Chemicals Ltd., Seal Sands Road, Seal Sands, Middlesbrough TS2 1UB, UK |
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| Abstract: | The α-Chloro-α-acetoxy-β-keto-esters were prepared from β-keto-esters in good overall yields. These compounds reacted as α,β-diketo-ester equivalents with amidrazones yielding triazines, generally in good yields, or with an amidrazone and 2,5-norbornadiene in a one-pot aza Diels-Alder reaction to give the corresponding pyridines. |
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| Keywords: | 1,2,4-Triazines α,β-Diketo-esters Aza Diels-Alder reaction |
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