An efficient ZrCl4 catalyzed one-pot solvent free protocol for the synthesis of 4-substituted coumarins |
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| Authors: | GVM Sharma J Janardhan Reddy P Sree Lakshmi P Radha Krishna |
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| Institution: | D-211, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A versatile and efficient route to 4-substituted coumarins via a Pechmann reaction using ZrCl4 as the catalyst (10 mol %) is described. This method provides several advantages over alternative procedures such as mild, solvent-free conditions at ambient temperature, and direct isolation of the products in high yields. |
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| Keywords: | Coumarins Phenols β-Ketoesters Pechmann reaction and ZrCl4 |
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