Kinetic resolution by copper-catalyzed azide-alkyne cycloaddition |
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| Authors: | Jun-cai Meng MG Finn |
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| Institution: | Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA |
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| Abstract: | The use of chiral pybox ligands imparts enantioselectivity to the CuI-catalyzed azide-alkyne cycloaddition reaction, in the form of kinetic resolution of α-chiral azides and desymmetrization of gem-diazides. While levels of selectivity are modest, the results show unequivocally that the process benefits from ligand-accelerated catalysis. |
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