The first stereoselective total synthesis of antiviral antibiotic, xanthocillin X dimethylether and its stereoisomer |
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| Authors: | Kuniaki Tatsuta Takahiro Yamaguchi |
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| Institution: | Department of Applied Chemistry, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan |
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| Abstract: | Xanthocillin X dimethylether (1) has been stereoselectively synthesized from the propiolic acid 6 through an oxidative rearrangement of the stannyl vinyl amide 27 to give the vinyl isocyanate 30 and a homocoupling of the stannyl N-formylenamine 31. |
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| Keywords: | Total synthesis Stannyl enamines Antiviral Vinyl isonitrile |
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