Tandem Hass-Bender/Henry reaction for the synthesis of dimethylnitro alcohols from benzylic halides |
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| Authors: | Thomas A Klein |
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| Institution: | Lilly Research Laboratories, A Division of Eli Lilly & Co., Lilly Corporate Center, Indianapolis, IN 46285, USA |
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| Abstract: | Dimethylnitro alcohols are constructed in a one-pot process from benzylic halides and 2-nitropropane. The use of tetrabutylammonium fluoride (TBAF) as the promoter is essential for this tandem Hass-Bender/Henry reaction to proceed. |
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| Keywords: | Hass-Bender reaction Henry reaction Tandem reaction TBAF |
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