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Solvent-free biocatalytic amidation of carboxylic acids |
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| Authors: | Ashok K Prasad Mofazzal Husain Brajendra K Singh Vijay K Manchanda Virinder S Parmar |
| Institution: | a Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 100 007, India b School of Biotechnology, GGSIP University, Kashmere Gate, Delhi 110 006, India c Radiochemistry Division, Bhabha Atomic Research Center, Mumbai 400 085, India d Chemistry Department, Royal Veterinary and Agricultural University, Frederiksberg C, DK-1871 Copenhagen, Denmark |
| Abstract: | Lipase-catalyzed enantioselective amidation was performed by reacting the racemic amine with aliphatic acids in nonsolvent system. The reaction equilibrium was shifted towards amide synthesis by the removal of water under reduced pressure. This methodology avoids the use of activating agents and hazardous solvents. |
| Keywords: | Lipase Enantioselective Amidation Bulk reaction Chiral amide |
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