Direct, pyrrolidine sulfonamide promoted enantioselective aldol reactions of α,α-dialkyl aldehydes: synthesis of quaternary carbon-containing β-hydroxy carbonyl compounds |
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| Authors: | Wei Wang Hao Li |
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| Affiliation: | a Department of Chemistry, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA
b School of Pharmacy, East China University of Science & Technology, PO Box 268, Shanghai 200237, China |
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| Abstract: | A procedure has been developed for direct, asymmetric aldol reactions of α,α-dialkyl aldehydes with aromatic aldehydes, which produces quaternary carbon-containing β-hydroxy carbonyl compounds. The processes, promoted by the organocatalyst (S) pyrrolidine sulfonamide, take place in high yields with exceptionally high levels of enantioselectivities. |
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| Keywords: | Aldehyde Aldol reaction Asymmetric catalysis Organocatalyst Pyrrolidine sulfonamide |
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