Efficient synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones using KAl(SO4)2·12H2O as a reusable catalyst in water and ethanol |
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| Authors: | Minoo Dabiri Peyman Salehi Mostafa Baghbanzadeh Ali A. Mohammadi |
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| Affiliation: | a Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, Tehran 1983963113, Iran
b Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran 19835-389, Iran |
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| Abstract: | KAl(SO4)2·12H2O was found to catalyze efficiently a one-pot three-component cyclocondensation of isatoic anhydride and primary amines or ammonia sources such as (NH4)2CO3, NH4OAc and NH4Cl with aromatic aldehydes under mild conditions to afford the corresponding mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones in good yields. |
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| Keywords: | KAl(SO4)2· 12H2O Multi-component reaction Cyclocondensation 2,3-Dihydroquinazolin-4(1H)-ones Reusable catalyst |
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