Copper-catalyzed enantioselective addition of alcohols to isatin-derived ketimines |
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| Authors: | Jian Lu Feng Sha Xin-Yan Wu |
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| Institution: | Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, PR China |
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| Abstract: | The first copper-catalyzed enantioselective addition of alcohols to imines was described. In the presence of 1?mol% Cu(OAc)2 complexed with chiral cyclohexane-based N,P-ligand L4, chiral isatin-derived N,O-aminals were obtained in excellent yields (93–99%) and good-to-excellent enantioselectivities (up to 93% ee) under mild conditions. |
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| Keywords: | Asymmetric catalysis Copper catalysis Ketimine Oxindole |
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